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Evidence summaries

Eradication of Helicobacter Pylori and Peptic Ulcer

Helicobacter pylori eradication (by triple therapy) is highly effective in curing peptic ulcer both in the short term and particularly in the long term. Level of evidence: "A"

A Cochrane review 4 (abstract , review [Abstract]) included 55 studies with 7 179 subjects. In duodenal ulcer healing, eradication therapy was superior to ulcer healing drug (UHD) (34 trials, 3910 patients, relative risk of ulcer persisting = 0.66; 95% CI 0.58, 0.76) and no treatment (2 trials, 207 patients, RR = 0.37; 95% CI 0.26, 0.53). In gastric ulcer healing, no significant differences were detected between eradication therapy and UHD (15 trials, 1 974 patients, RR = 1.23; 95% CI = 0.90, 1.68). In preventing duodenal ulcer recurrence no significant differences were detected between eradication therapy and maintenance therapy with UHD (4 trials, 319 patients, RR of ulcer recurring = 0.73; 95% CI = 0.42, 1.25), but eradication therapy was superior to no treatment (27 trials 2509 patients, RR = 0.20; 95% CI = 0.15, 0.26). In preventing gastric ulcer recurrence, eradication therapy was superior to no treatment (12 trials, 1 476 patients, RR = 0.31; 95% CI 0.22, 0.45).

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Primary/Secondary Keywords