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Evidence summaries

Terlipressin for Hepatorenal Syndrome

Terlipressin appears to reduce mortality and improve renal function in hepatorenal syndrome. Level of evidence: "B"

A Cochrane review [Abstract] 1 included 9 studies with 534 participants.

In total, 473 participants had type 1 hepatorenal syndrome. Seven RCTs specifically evaluated terlipressin and albumin. Terlipressin was associated with a beneficial effect on mortality when including all RCTs (RR 0.85, 95% CI 0.73 to 0.98; 534 participants; number needed to treat for an additional beneficial outcome (NNTB) 10.3 people). Trial Sequential Analysis including all RCTs also found a beneficial effect of terlipressin. Additional analyses showed a beneficial effect of terlipressin and albumin on reversal of hepatorenal syndrome (RR 0.63, 95% CI 0.48 to 0.82; 510 participants; 8 RCTs; NNTB 4 people). Terlipressin increased the risk of serious cardiovascular adverse events (RR 7.26, 95% CI 1.70 to 31.05; 234 participants; 4 RCTs), but it had no effect on the risk of serious adverse events when analysed as a composite outcome (RR 0.91, 95% CI 0.68 to 1.21; 534 participants; 9 RCTs; number needed to treat for an additional harmful outcome 24.5 people). Non-serious adverse events were mainly gastrointestinal, including diarrhoea (RR 5.76, 95% CI 2.19 to 15.15; 240 participants) and abdominal pain (RR 1.54, 95% CI 0.97 to 2.43; 294 participants).

Comment: The quality of evidence is downgraded by imprecise results (few patients and wide confidence intervals) and by potential reporting bias.

    References

    • Allegretti AS, Israelsen M, Krag A et al. Terlipressin versus placebo or no intervention for people with cirrhosis and hepatorenal syndrome. Cochrane Database Syst Rev 2017;(6):CD005162. [PubMed]

Primary/Secondary Keywords