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Evidence summaries

Interventions for Hidradenitis Suppurativa

In patients with hidradenitis suppurativa (HS), adalimumab and infliximab improve quality of life but the effect size is small and may not be clinically relevant. Level of evidence: "C"

Summary

A Cochrane review [Abstract] 1 included 12 studies with a total of 615 subjects. The median number of participants in each trial was 27, and median trial duration was 16 weeks. A single RCT that was underpowered to detect clinically meaningful differences investigated most interventions.There were four trials of anti-TNF-α (tumour necrosis factor-alpha) therapies, which included etanercept, infliximab, and adalimumab.

Adalimumab 40 mg weekly improved the Dermatology Life Quality Index (DLQI) score in participants with moderate to severe HS by 4.0 points relative to placebo (95% CI -6.5 to -1.5 points), an effect size approximately equal to the DLQI minimal clinically important difference. In a meta-analysis of two studies with 124 participants, standard dose adalimumab 40 mg every other week was ineffective compared with placebo. In a smaller study of 38 participants, of whom only 33 provided efficacy data, infliximab 5 mg/kg treatment improved DLQI by 8.4 DLQI points after eight weeks. Etanercept 50 mg twice weekly was well tolerated but ineffective.In a RCT of 200 participants, no difference was found in surgical complications (week one: RR 0.78, 95% CI 0.58 to 1.05) or risk of recurrence (after three months: RR 0.96, 95% CI 0.68 to 1.34) in those randomised to receive a gentamicin-collagen sponge prior to primary closure compared with primary closure alone.RCTs of other interventions, including topical clindamycin 1% solution; oral tetracycline; oral ethinylestradiol 50 mcg with either cyproterone acetate 50 mg or norgestrel 500 mcg; intense pulsed light; neodymium-doped yttrium aluminium garnet (Nd:YAG) laser; methylene blue gel photodynamic therapy; and staphage lysate, were relatively small studies, preventing firm conclusions due to imprecision.

Clinical comments

Note

Date of latest search: 2015-08-13

    References

    • Ingram JR, Woo PN, Chua SL et al. Interventions for hidradenitis suppurativa. Cochrane Database Syst Rev 2015;(10):CD010081. [PubMed]

Primary/Secondary Keywords