Acute Coronary Syndrome

Antithrombotic therapy Fondaparinux for Acute Coronary Syndromes

• A decision on starting the administration of an ADP receptor inhibitor (ticagrelor, clopidogrel, prasugrel) should be made only after contrast-enhanced imaging. The drug should be chosen according to the local guidelines and to the clinical assessment of the patient.
  • Initial loading doses:
    • ticagrelor 180 mg (continued with 90 mg twice daily)
    • clopidogrel 600 mg (continued with 75 mg/day)
    • prasugrel 60 mg (continued with 10 mg once daily)
  • The effect of clopidogrel has a slower onset, and in some patients (about 20 %) its anti-platelet effect may remain inadequate.
  • If contrast-enhanced imaging cannot be arranged within 24 hours, starting an ADP receptor inhibitor already before such imaging should be considered.
• Low molecular weight heparin Low Molecular Weight Heparins for Acute Coronary Syndromes: enoxaparin 1 mg/kg twice daily s.c.; the dose should be reduced in patients over 75 years (-25%) and in renal failure (GFR < 30 ml/min, -50%).
• Thrombolysis is of no benefit.
• If the patient is being treated with an anticoagulant
  • Warfarin therapy with INR in the therapeutic range (2.0-3.0) should be continued without interruption instead of heparin treatment. If INR is below the therapeutic range, anticoagulation with warfarin can be continued at discretion together with a reduced dose of heparin until the target INR level has been reached, or with heparin only. If INR is too high, warfarin should be paused. The action of warfarin can be reversed by administering Vitamin K1 (phytomenadione, Konakion^® ) 1-3 mg intravenously, even though there is only limited evidence of its benefit. Treatment with warfarin may then be continued. INR should be determined daily, if warfarin is continued.
  • If the patient is using a direct oral anticoagulant (dabigatran, rivaroxaban, apixaban, edoxaban), it need not normally be paused.. Local guidelines should be followed and a cardiologist performing invasive prodecures consulted.
  • Start aspirin and, after contrast-enhanced imaging, clopidogrel, as necessary, for patients on anticoagulants. Use of ticagrelor and prasugrel should be avoided.
• Always remember to assess the risk of thrombosis (CHA₂DS₂-VASc) and bleeding (HAS-BLED) (see tables in Indications for and Implementation of Anticoagulant Therapy in Atrial Fibrillation). Factors increasing the risk of bleeding include anaemia, thrombocytopenia, age > 75 years, renal failure, liver failure, female gender, weight < 65 kg, systolic BP >160 mmHg, a previous history of a bleeding tendency and medications affecting the platelet function.

Anti-ischaemic and other treatment Statins for Acute Coronary Syndrome, Early Treatment with ACE Inhibitors in Acute Myocardial Infarction, Beta-Blockers after Acute Myocardial Infarction

• A nitrate infusion if the chest pain persists, blood pressure is elevated or there are signs of heart failure. The patient must not be hypotensive (systolic BP should be > 100-110 mmHg) or hypovolaemic nor exhibit signs of right ventricular infarction. Nitrate infusion is more effective than the drug administered orally.
  • The initial dose is 13-20 µg/min = 8-12 ml/hour when the concentration is 100 µg/ml. If necessary, the dose may be increased every few minutes up to 120 ml/h whilst closely monitoring blood pressure.
• A beta blocker (metoprolol) intravenously as 2.5-5 mg bolus doses if blood pressure is elevated or tachycardia or arrhythmias occur (be careful if the patient has hypotension < 120 mmHg or heart failure). A beta blocker already in use should be continued, provided that there is no hypotension or cardiac failure.
  • Starting an oral beta blocker should be considered within the first 24 hours, after haemodynamic stabilization, if the patient has heart failure or left ventricular dysfunction and if there are no contraindications for the drug.
• An ACE inhibitor should be started within the first 24 hours of treatment in patients with heart failure, systolic left ventricular dysfunction, anterior wall infarction or diabetes. Low blood pressure (systolic BP < 100 mmHg) should be avoided; exercise caution if the patient has renal failure.
• Early introduction of a statin, i.e. during the first day of treatment, at a high therapeutic dose is recommended.
• NSAIDs should be stopped and should not be used for pain relief.
• A PPI should be considered when an anticoagulant and/or aspirin and/or an ADP receptor inhibitor is in use. The risk of GI bleeding is also increased by a history of GI bleeding, continuous glucocorticoid or NSAID medication, age > 65 years, dyspepsia, reflux disease and excessive use of alcohol.

Invasive treatment, revascularization (PTCA and CABG)

• Urgent invasive assessment and treatment without delay
  • If the patient is in cardiogenic shock, if he/she has chest pains despite treatment, or if the haemodynamic state is regarded as unstable (arrhythmias, hypotension, heart failure).
• Early invasive assessment and treatment 24-72 h
  • Individual risk assessment and timing of the invasive investigation according to its results (e.g. < 24 hours or < 72 hours); see table T5
  • Signs of increased risk (recurrent ST-T fluctuations, high release of cardiac biomarkers, heart failure, earlier PCI/CABG, diabetes, renal failure) have an influence on the more specific timing of the investigation.
• In most cases only the occluded infarct-related artery is treated, and other possible stenoses are treated at a later date.

Initial management

• See above here.
• If the ST elevation is corrected with nitrate, the underlying condition may be a coronary artery spasm either with or without an acute myocardial infarction. A cardiologist should be consulted; in case of a suspected infarction coronary angiography should be performed within < 24 hours, and if ST elevation and chest pain recur, without delay.

Reperfusion: emergency percutaneous coronary intervention (PCI) / thrombolytic therapy Complete Versus Culprit-Only Revascularization in ST-Elevation Myocardial Infarction

• Choosing the most suitable reperfusion treatment option according to the patient's needs and local conditions requires consultation with a cardiologist on call or with an emergency physician at a hospital.
• The first-line choice for reperfusion treatment is a primary PCI (PPCI) if that can be performed within less than 120 minutes after making the diagnosis. Thrombolytic therapy is an alternative if PPCI is not available.
• A PPCI is the first-line choice particularly if > 3 hours have passed since the onset of infarct pain, if there are contraindications for thrombolytic therapy (table T6) or if there is no treatment response to thrombolytic therapy within 60 minutes, or if the patient is hemodynamically unstable or a high-risk patient. Also uncertainty of the STEMI diagnosis (ventricular pacing, LBBB, difficulty in interpreting the ECG) speak for a PPCI.
  • Immediate PCI is the primary choice for the treatment of, particularly, elderly patients and those with risk of haemorrhage.
• Coronary angiograpy and a PPCI is recommended for patients
  • whose symptoms have continued for > 12 hours
  • whose ECG shows signs of ischaemia
  • who have recurrent chest pain and dynamic ECG changes, or signs of cardiac failure, of arrhythmias that threaten haemodynamics or of a cardiogenic shock.
• The results achieved with thrombolytic therapy are best if it is started rapidly within 1-2 hours of symptom onset. If a PPCI is not available, it is recommended to consider thrombolytic therapy for patients whose symptoms have started less than 12 hours ago if there are no contraindications for thrombolytic therapy (table T6). The benefit of the treatment is markedly reduced when more than 6 hours have elapsed from symptom onset and no benefit is to be expected when more than 12 hours have elapsed from the symptom onset.
• Agents used in thrombolytic therapy and their doses are presented in table T7.

• Patients who arrive for treatment with delay (12-48 h from the onset of symptoms) with no pain and even in a haemodynamically stable condition, who have had a STEMI may benefit from invasive assessment and treatment. Haemodynamically stable patients with no pain who have had an infarction more than 48 hours ago do not benefit from a routine revascularization of the infarct vessel.

Other medication in association with reperfusion Low-Molecular Weight Heparin in Patients with Acute Myocardial Infarction Treated with Thrombolytic Therapy

• Consult first with the cardiologist on call at the cardiology unit regarding the feasibility of primary PCI and the antithrombotic medication.
• Aspirin 250 mg to chew and swallow or 150 mg intravenously before both thrombolytic therapy and PPCI (see initial management here)
• For other antithrombotic medication alternatives for patients with STEMI, see Table T8. Check local guidelines for treatment.
• Patients on anticoagulation therapy
  • Warfarin treatment within therapeutic range (INR 2.0-3.0) is continued. INR should be monitored daily; heparin therapy should not be started.
  • Direct anticoagulant therapy should be paused. Local guidelines should be followed and a cardiologist on call consulted.
• Patients with STEMI who decline reperfusion therapy, or in whom it is not possible due to comorbidities, should be treated with aspirin and/or clopidogrel (doses as prior to thrombolytic therapy) and with enoxaparin, or as considered suitable in the given situation.

Complications of thrombolytic therapy

• Intracranial bleed is a rare (1-2%) but serious complication of thrombolytic therapy. The signs of intracranial haemorrhage include a reduced level of consciousness, confusion and neurological deficits.
  • If haemorrhage is suspected, a CT scan of the head must be carried out.
• Intestinal and other bleeds (haematemesis, melaena) are more frequent (5-10%) than intracranial haemorrhage.
• Bleeding complications associated with thrombolytic therapy usually appear within 24 hours.
• Age > 75 years, female gender, systolic BP > 160 mmHg, lower body weight and concurrent anticoagulant therapy are factors increasing the risk haemorrhage.

Assessment of revascularization

• The most useful sign of successful thrombolysis is ST segment resolution HASH(0x2fdd378) 50% in the lead with the highest elevation within 60-90 minutes of the start of thrombolytic therapy.
• Alleviation of chest pain and reperfusion arrhythmias are suggestive findings but when appearing alone are not sufficient to confirm revascularization.
• Thrombolysis fails in about one third of patients, and reocclusion develops during hospitalisation in about 20% of patients after initial successful thrombolysis. In a large share of patients a significant occlusion remains in the coronary artery after thrombolysis.
• Patients who have received thrombolytic therapy are transported to a hospital with the capacity to perform a PPCI, where a coronary angiograpy is carried out within 24 hours,

Causes

• The mechanisms of arrhythmias include myocardial ischaemia and damage, reperfusion changes, autonomic imbalances as well as electrolyte and acid-base disturbances.
• Rapid reperfusion therapy (PPCI) should be pursued if any of the following is detected: ventricular fibrillation (VF), ventricular tachycardia (VT), frequent ventricular ectopic beats or disturbances in the AV conduction.

Ventricular fibrillation (VF)

• Primary VF occurring within 24-48 hours does not increase long-term risk of an arrhythmia or mortality.
• VF is treated with immediate defibrillation. Recurrent VF should be treated with defibrillation and by starting a beta blocker and/or amiodarone. Ischaemia induces recurrent VF; therefore, it should be rapidly evaluated by coronary angiography and revascularisation should be pursued.
• The risk of recurrence can be reduced by drug therapy for myocardial ischaemia and heart failure (adequate beta blockade, ACE inhibitors, nitrates). Similarly, electrolyte disturbances must be corrected as well as factors associated with fluid balance and oxygenation.

Ventricular tachycardia (VT)

• Repeated and prolonged episodes of VT are suggestive of a worsening heart disease and ischaemia, and when recurring they are an indication for rapid coronary angiography/PPCI.
• If VT episodes recur frequently, either a beta blocker or amiodarone should be administered intravenously. When VT is sustained or causes haemodynamic instability, it should be treated with immediate cardioversion, which is repeated as required.

Other ventricular arrhythmias

• Ventricular ectopic beats are common in patients with MI during the first few days of treatment. If they are asymptomatic and hemodynamically well-tolerated, no specific treatment is required.
• Idioventricular rhythm is a consequence of reperfusion and requires no specific treatment. Similarly, episodes of non-sustained VT (< 30 seconds) without haemodynamic effects require no specific treatment. None of the above mentioned arrhythmias serve as reliable predictors of VF.

Atrial fibrillation (AF)

• AF is common in the acute phase of an MI (10-20%). It increases in-hospital mortality and the risk of stroke, also in long-term follow-up.
• It is more prevalent in older patients with MI and in patients with left ventricular dysfunction or heart failure.
• Anticoagulant therapy should be started unless the patient is already on anticoagulant treatment; long-term therapy according to CHA₂DS₂-VASc criteria (see table inIndications for and Implementation of Anticoagulant Therapy in Atrial Fibrillation); need for antithrombotic medication should be considered.
• In the case of AF with rapid ventricular rate, an intravenous, later oral beta blocker should be used to reduce ventricular rate. If the patient has cardiac failure or beta blockers are not suitable or not effective enough, intravenous amiodarone or digoxin may be used.

Sinus bradycardia and AV conduction disturbances

• Sinus bradycardia is common in the first few hours of an MI, particularly in inferior infarction. Medication reducing heart rate should be paused. Opioids may predispose to sinus bradycardia. If sinus bradycardia causes haemodynamic compromise it should be treated with atropine 0.5 mg intravenously, followed by supplemental doses of 0.2-0.3 mg up to 2.0 mg.
• First-degree AV block is often associated with inferior wall damage and is usually transient requiring no treatment.
• More serious conduction disturbances, such as second- and third-degree AV block as well as LBBB, RBBB and left fascicular block indicate extensive myocardial damage and a rapid coronary angiography is required. In such cases, temporary, sometimes even permanent, pacing is required. In second-degree AV block, atropine may improve the conduction. Isoprenaline may provide temporary help. Transient AV block is most commonly associated with an inferior MI.

Antiarrhythmic medication

• Antiarrhythmic and antibradycardia medications are presented in table T9.

Monitoring and care

• Continuous cardiac monitoring in a surveillance unit is indicated during the first few treatment days.
• In an uncomplicated MI, a patient without chest pain is allowed to sit up straightaway, eat unassisted and use the commode at the bedside.
• In a complicated MI (heart failure, arrhythmias) bed rest should continue longer (2-4 days), mobilisation when considered appropriate.
• An ACE inhibitor Early Treatment with ACE Inhibitors in Acute Myocardial Infarction should be introduced during the first 24 hours of treatment. If an ACE inhibitor is not suitable, an angiotensin receptor blocker should be prescribed.
• A beta blocker should be started during the hospitalisation period when the patient is haemodynamically stable.
• Nicotine replacement therapy is introduced for smokers Nicotine Replacement Therapy for Smoking Cessation.
• Patient education and motivation for treatment is important. The patient should be given information about the disease, the modification of risk factors and other medication.

Treatment chain

• Treatment of a patient with MI may justifiably be carried out within primary care if the treatment options are limited due to other diseases.