section name header

Evidence summaries

Single Versus Double Intrauterine Insemination (Iui) in Stimulated Cycles for Subfertile Couples

Double intrauterine insemination in stimulated cycles may not to result in higher live birth rate compared to single intrauterine insemination in the treatment of subfertile couples. Level of evidence: "C"

A Cochrane review [Abstract] 1 included 9 studies with a total of 2 716 women. There was no significant difference in live birth rate (OR 1.15, 95% CI 0.71 to 1.88; I² 29%; 3 studies n=468; low quality evidence). The evidence suggests that if the chance of live birth following single intrauterine insemination (IUI) is 16%, the chance of live birth following double IUI would be between 12% and 27%.

A meta-analysis 2 included 15 RCTs with a total of 3 795 women. The subgroup 'mild male infertility' included 1246 women whilst the subgroup 'normal semen quality' included 1188 women. Clinical pregnancy was reported by all studies, and there is no evidence of a difference between single and double IUI (RR 1.22, CI 0.97 to 1.54, 15 RCTs, 3 795 women, I² 45%). In the subgroup analysis, no particular group that could benefit was identified. Live birth, ectopic pregnancy, and miscarriage were reported in very few studies and the estimates were too imprecise.

Comment: The quality of evidence is downgraded by study quality (unclear allocation concealment and inadequate intention-to-treat adherence) and imprcise results (few events and wide confidence intervals).

    References

    • Rakic L, Kostova E, Cohlen BJ et al. Double versus single intrauterine insemination (IUI) in stimulated cycles for subfertile couples. Cochrane Database Syst Rev 2021;(7):CD003854. [PubMed]
    • Arab-Zozani M, Nastri CO. Single versus double intrauterine insemination (IUI) for pregnancy: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol 2017;(215):75-84. [PubMed]

Primary/Secondary Keywords