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Evidence summaries

Effect of Cyclosporine on Blood Pressure

Cyclosporine increases blood pressure compared to placebo in a dose-related fashion. Level of evidence: "A"

A Cochrane review [Abstract] 1 included 17 studies with a total of 1 094 subjects. Cyclosporine use increased blood pressure; the overall magnitude was 7.4 mmHg with a range from 2.5 to 16.4 mmHg. There appeared to be a dose-related effect with lower doses (1-4 mg/kg/d) increasing mean BP by an average of 5.0 mmHg (95% CI 2.8 to 7.2 mmHg) and higher doses (>10 mg/kg/d) increasing mean BP by 11.4 mmHg on average (95% CI 7.2 to 15.6 mmHg). Furthermore in 3 trials the effect appeared to be similar after a single dose as with chronic therapy.

    References

    • Robert N, Wong GW, Wright JM. Effect of cyclosporine on blood pressure. Cochrane Database Syst Rev 2010;(1):CD007893. [PubMed]

Primary/Secondary Keywords