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Evidence summaries

Cyclosporine A in Severe Ulcerative Colitis

Cyclosporine may be more effective than standard treatment alone for severe ulcerative colitis but seems not to prevent colectomy. Level of evidence: "C"

A Cochrane review [Abstract] 1 included two studies with a total of 50 subjects. In the first trial, 11 patients received intravenous cyclosporine (4 mg/kg) and 9 received placebo. Two of 11 in the treatment group failed to respond to therapy compared with 9/9 in the placebo group (RR 0.18, 95% CI 0.05-0.64). However, 3/11 and 4/9 eventually underwent colectomy in the treatment and placebo groups respectively and follow-up was less than a month.

In the second trial 15 patients were treated with intravenous cyclosporine and 15 with intravenous methylprednisolone. Five of 15 patients in the cyclosporine group failed to respond to therapy as compared to 7/15 in the methylprednisolone group (RR 0.71, 95% CI 0.29-1.75). After 1 year 7/9 responders in the cyclosporine group were still in remission compared with 4/8 in the steroid group (p > 0.05) and the colectomy rate was similar in both groups. The mean time to response in the cyclosporine group in the 2 trials was short (7 days and 5.2 days).

Comment: The results should be interpreted with caution given the small numbers of trials and patients evaluated for comparison, and limited follow-up. The relatively quick response makes the short-term use of cyclosporine potentially attractive, but the long-term benefit is unclear, when adverse events such as cyclosporine-induced nephrotoxicity may become more obvious.

    References

    • Shibolet O, Regushevskaya E, Brezis M, Soares-Weiser K. Cyclosporine A for induction of remission in severe ulcerative colitis. Cochrane Database Syst Rev 2005 Jan 25;(1):CD004277 [Last assessed as up-to-date: 13 July 2008]. [PubMed]

Primary/Secondary Keywords