Knee or foot orthoses might possibly be effective in the short term in decreasing pain associated with the patellofemoral pain syndrome in adults, but the results in the long term are pending Nonoperative Therapy for Patellofemoral Pain Syndrome.
There is only limited evidence for the effectiveness of NSAIDs in patellofemoral pain syndrome. The evidence for the effect of glycosaminoglycan polysulphate is contradictory Pharmacotherapy for Patellofemoral Pain Syndrome.