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Information

Editors

MattiSeppänen

Central Serous Retinopathy

Essentials

  • Central serous retinopathy (CSR, also known as central serous chorioretinopathy, CSCR) causes painless reduction of visual acuity due to accumulation of fluid underneath the retina.
  • Typically a disease of the young and middle-aged, often associated with high stress exposure
  • In the acute form of the disease, no treatment is usually necessary (good spontaneous healing tendency).
  • The chronic form may cause permanent visual damage; laser treatment or pharmacotherapy should be considered.
  • The patients should be treated by an ophthalmologist.

Incidence

  • The fifth most common retinal disease
  • Six times more common in men than in women

Risk factors

  • Stress
    • Imbalance of the sympathetic and parasympathetic nervous systems
    • Hypertension
    • Exogenous and endogenous glucocorticoids
  • Heredity

Symptoms and findings

  • Reduced visual acuity
  • Distortion of text and lines (metamorphopsia)
  • Change of refractive power towards hyperopia (need for increased plus power in glasses)
  • Visual field defect
  • Disturbances of colour vision
  • Often unilateral but may be bilateral
  • Distortion or blurring on Amsler chart
  • Optical coherence tomography (OCT) of the ocular fundus showing fluid accumulation underneath the retina

Workup

Differential diagnosis

Treatment

  • Avoidance of stressors
  • If the patient is on glucocorticoids, these should be withdrawn as far as possible.
  • The acute form of the disease (less than 3 months) usually heals spontaneously without any treatment.
  • The chronic form (more than 3 months) may cause permanent loss of vision.
    • Photodynamic therapy should be considered: intravenously administered verteporfin activated in the ocular blood vessels by red light.

Pharmacotherapy