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Evidence summaries

Methotrexate for Psoriasis

Methotrexate may induce and maintain remission in patients with severe psoriasis. Level of evidence: "C"

According to a systematic review 1 there is a lack of RCT evidence to support the use of methotrexate. Despite this lack of RCT data, it is important to note that open and retrospective studies suggest that methotrexate is effective in inducing and maintaining remission in patients with severe psoriasis.

References

  • Griffiths CEM, Clark CM, Chalmers RJG,Li Wan Po A, Williams HC.A systematic review of treatments for severe psoriasis. Health Technol Assess 2000;4(40).

Primary/Secondary Keywords