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Evidence summaries

Dose-Response Effect of Aspirin on Stroke

Across a broad range of aspirin doses, from 50 to 1500 mg/day the risk ratio for stroke is essentially uniform. Level of evidence: "A"

A systematic review 1 including 11 RCTs with a total of 9629 subjects (5228 receiving aspirin) was abstracted in DARE. The linear regression model confirmed that there is no linear dose-response trend, and the stratified Mantel-Haenszel test for heterogeneity confirmed that the RRs were similar across studies. The pooled RR across studies for any aspirin dose gave a risk reduction of 15% (95% CI 6% to 23%).

    References

    • Johnson ES, Lanes SF, Wentworth CE 3rd, Satterfield MH, Abebe BL, Dicker LW. A metaregression analysis of the dose-response effect of aspirin on stroke. Arch Intern Med 1999 Jun 14;159(11):1248-53. [PubMed] [DARE]

Primary/Secondary Keywords