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Evidence summaries

Sulphasalazine for Psoriasis

Sulphasalazine appears to be moderately effective for psoriasis but may not be usable because of side-effects. Level of evidence: "B"

According to a systematic review 1 only one RCT assessed the use of sulphasalazine in the treatment of severe psoriasis. This trial found that sulphasalazine was a moderately effective and potentially long-term treatment. However, the drug´s efficacy was offset to a degree by patient intolerance and side-effects, particularly nausea, vomiting and rashes.

    References

    • Griffiths CEM, Clark CM, Chalmers RJG,Li Wan Po A, Williams HC.A systematic review of treatments for severe psoriasis. Health Technol Assess 2000;4(40).

Primary/Secondary Keywords