Crohn's Disease - Related Resources
Cochrane reviews
- Laparoscopic surgery may be as safe as open operation for small bowel Crohn's disease Laparoscopic Versus Open Surgery for Small Bowel Crohn's Disease
- 5-ASA preparations appear to be effective in maintaining surgically induced remission compared to placebo in patients with Crohn's disease, but the benefit is modest (NNT 16 to 19)Oral 5-Aminosalicylic Acid for Maintenance of Surgically-Induced Remission in Crohn's Disease.
- Recombinant human interleukin 10 might possibly increase the number of remissions, complete or clinical, compared to placebo in the treatment of refractory Crohn's disease, but the evidence is insufficient for conclusions Recombinant Human Interleukin 10 for Induction of Remission in Crohn's Disease.
- Oral budesonide (9 mg/day for 8 to 10 weeks) is effective for the treatment of acute flares of Crohn's disease. It is somewhat less efficacious but with fewer adverse effects than conventional corticosteroids Budesonide for Induction of Remission in Crohn's Disease.
- Oral budesonide 3-6 mg daily is not more effective than placebo or weaning prednisolone for maintenance of remission in Crohn's diseaseBudesonide for Maintenance of Remission in Crohn's Disease.
- High dose intramuscular methotrexate may be effective in induction of remission in refractory Crohn's disease Methotrexate for Induction of Remission in Refractory Crohn's Disease.
- Low dose oral cyclosporine may be ineffective for treatment of active Crohn's disease and entails risk of nephrotoxicity Cyclosporine for Induction of Remission in Crohn's Disease.
- Infliximab may be effective for induction of remission in Crohn's disease Infliximab in Crohn's Disease.
- TNF-alpha blocking agents infliximab, adalimumab, and certolizumab pegol are effective for maintenance of remission in patients with Crohn's disease who have a clinical response to induction therapy Tumor Necrosis Factor-Alpha Antibody for Maintenace of Remission in Crohn's Disease.
- Natalizumab is effective for induction of clinical response and remission in some patients with moderately to severely active Crohn's disease, but the clinical benefit should be weighed against the potential risk of serious adverse events Natalizumab for Induction of Remission in Crohn's Disease.
- Omega 3 fatty acids seem to be effective for maintenance of remission in Crohn's disease although the evidence is insufficientOmega 3 Fatty Acids (Fish Oil) for Maintenance of Remission in Crohn's Disease.
- Enteral nutritional supplementation using elemental or polymeric formulas may be effective for maintenance of remission in Crohn's disease Enteral Nutrition for Maintenance of Remission in Crohn's Disease.
- Pentasa may decrease the activity of Crohn's disease compared with placebo in patients with active disease Oral Pentasa in the Treatment of Active Crohn's Disease.
- There is insufficient evidence about the efficacy of probiotics for induction of remission in Crohn's disease Probiotics as Add-on Treatments to Corticosteroids for Induction of Remission in Crohn's Disease.
- Lenalidomide appears no to be effective for induction of remission in Crohn's disease compared to placebo Thalidomide and Thalidomide Analogues for Induction of Remission in Crohn's Disease.
- Mesalamine, azathioprine/6-MP, and nitro-imidazoleantibiotics appear to be superior to placebo for the prevention of post-operative recurrence of Crohn's disease Interventions for Prevention of Post-Operative Recurrence of Crohn's Disease.
- Intramuscular methotrexate at a dose of 15 mg/week appears to be safe and effective for maintenance of remission in Crohn's disease. There is insufficient evidence on lower doses given orally Methotrexate for Maintenance of Remission in Crohn's Disease.
- There is insufficient evidence on the impact of specialist nursing interventions on the care and management of patients with inflammatory bowel disease Specialist Nursing Interventions for Inflammatory Bowel Disease.
- Ciprofloxacin may be more effective than metronidazole, while budesonide enemas and metronidazole may be similarly effective for acute pouchitis, and VSL#3 (probiotic bacteria formulation) may be more effective than placebo in maintaining remission in chronic pouchitisTreatment of Pouchitis.
- Aminosalicylates may be more effective than placebo but less effective than corticosteroids in inducing remission in Crohn's colitis. Aminosalicylates for Induction of Remission or Response in Crohn's Disease
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