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Evidence summaries

Hepatic Resection as a Treatment for Liver Metastases in Colorectal Cancer

There may be a clear survival advantage for patients who have liver resection. Level of evidence: "C"

A systematic review 1 including 19 case series studies with a total of 5 765 subjects was abstracted in DARE. Based on the reported survival outcomes for the treated populations as a whole, fiver year survival following surgical resection ranges between 21% and 41% compared with <5% in similar patients without surgical intervention. Despite the number and size of tumours there are clear survival advantages for patients with multiple metastases if the resection can successfully remove all of the metastases without positive margins. The operative mortality is in the range 0-4%.

    References

    • Beard SM, Holmes M, Majeed A, Price C. Hepatic resection as a treatment for liver metastases in colorectal cancer. Guidance Note for Purchasers. Sheffield: University of Sheffield, Trent Institute for Health Services Research. Guidance Notes for P. 1999. 1-67. [DARE]

Primary/Secondary Keywords