A Cochrane review [Abstract] 1 included 6 studies with a total of 456 subjects. From the limited data, the live birth rate per couple randomly assigned (27% vs 0%; Peto odds ratio (OR) 9.31, 95% confidence interval (CI) 1.17 to 73.75; one study, n=30) and the spontaneous pregnancy rate per couple randomly assigned (16% vs 7%; Peto OR 4.94, 95% CI 2.13 to 11.44; 5 studies, n=412, I²=0%) were significantly higher in men receiving gonadotrophin treatment than in men receiving placebo or no treatment. No significant difference between groups was noted when intracytoplasmic sperm injection (ICSI) or intrauterine insemination (IUI) was performed. None of the included studies reported miscarriage rates, and adverse events data were sparse.
Comment: The quality of evidence is downgraded by limitations in study quality (unclear allocation concealment and lack of blinding in some studies) and by potential reporting bias (only few small trials reported).
Primary/Secondary Keywords