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Evidence summaries

Parenteral Dosing of Clindamycin

600 mg of clindamycin every 8 hours is effective in pelvic infections. In abdominal infections 900 mg every 8 hours may be more effective, although the difference is not statistically significant and is not based on direct comparison of the doses. Level of evidence: "C"

A systematic review 1 including 23 studies with a total of 1,131 subjects with abdominal or pelvic infections was abstracted in DARE. The dosing regiments were either 600 mg every 8 hours or 900 mg every 8 hours. The mean weighted cure rate for in abdominal infection was 76% (95% CI 59% to 92%) with the lower dosage, and 91% (95% CI 85% to 96%) with the higher dose. In pelvic infections the mean weighted cure rate was 83% with the lower dose and 89% with the higher dose.

Comment: The quality of evidence is downgraded by study quality (limited information of the studies) and by potential reporting bias (limited search).

References

  • Rovers JP, Ilersich AL, Einarson TR. Meta-analysis of parenteral clindamycin dosing regimens. Ann Pharmacother 1995 Sep;29(9):852-8. [PubMed] [DARE]

Primary/Secondary Keywords