Septicaemia - Related Resources

Cochrane reviews

Polychlonal intravenous immunoglobulin seems to reduce mortality in sepsis, but monochlonal antibodies may not be effective, although the evidence is insufficientIntravenous Immunoglobulin for Treating Sepsis and Septic Shock.
Low dose of corticosteroids for five days is effective in improving survival in septic shock without causing harm Corticosteroids for Treating Sepsis.
Adding an aminoglycoside to beta-lactams in the treatment of sepsis does not improve clinical efficacy achieved with the beta-lactam alone. Combination treatment carries a significant risk of nephrotoxicity Combination of Beta Lactam and Aminoglycoside Antibiotic Therapy for Sepsis.
Activated protein C (APC) is not effective in reducing mortality in patients with sepsisHuman Recombinant Activated Protein C for Severe Sepsis.
Hydroxyethyl starch colloids for fluid resuscitation in septic patients appear to decrease kidney function compared to other fluid therapy Hydroxyethyl Starch (Hes) Versus other Fluid Therapies: Effects on Kidney Function.
Naloxone may be beneficial in septic shock, but the number of patients studied is small and there is a possibility of publication bias Naloxone for Shock.

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock (2016) http://www.survivingsepsis.org/Guidelines/Pages/default.aspx

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