Quality of evidence is downgraded by two levels due to serious risk of bias (performance bias (blinding was not specified), attrition bias and selective reporting bias) and serious imprecision (optimal information size criteria not achieved).
A Cochrane review [Abstract] 1 included 3 studies with a total of 124 subjects. One study in 64 participants found that a simulated descent of 193 millibars versus 20 millibars may reduce the average of symptoms to 2.5 vs 3.1 units after 12 hours of treatment (clinical score ranged from 0 to 11 ‒ worse; reduction of 0.6 points on average with the intervention; low quality of evidence). In addition, no complications were found with use of hyperbaric chambers versus supplementary oxygen (one study; 29 participants; low-quality evidence). All cause mortality and complete relief of acute mountain sickness symptoms were not reported.
Date of latest search: 20th August 2018
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