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Evidence summaries

Colchicine for Alcoholic and Non-Alcoholic Liver Fibrosis and Cirrhosis

Colchisine is not effective for cirrhosis, and causes adverse effects. Level of evidence: "A"

A Cochrane review [Abstract] 1 included 15 studies with a total of 1714 subjects. There was no significant effect of colchicine versus placebo/no intervention on mortality (relative risks (RR) 1.00, 95% CI 0.87 to 1.16), liver-related mortality (RR 1.08, 95% CI 0.88 to 1.33), complications (RR 1.01, 95% CI 0.74 to 1.38), liver biochemistry, liver histology, or alcohol consumption (RR 1.03, 95% CI 0.77 to 1.39). Colchicine was associated with a significantly increased risk of serious adverse events (RR 8.38, 95% CI 1.08 to 65.2).

    References

    • Rambaldi A, Gluud C. Colchicine for alcoholic and non-alcoholic liver fibrosis and cirrhosis. Cochrane Database Syst Rev 2005 Apr 18;(2):CD002148. [PubMed]

Primary/Secondary Keywords