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Evidence summaries

Maintenance Therapy with Triple Versus Double Immunosuppressive Regimens in Renal Transplantation

There is probably no statistically significant difference in outcome after triple compared with double therapy. Level of evidence: "C"

A systematic review 1 including 5 studies with a total of 907 subjects was abstracted in DARE. Pooled analysis did not show statistically significant difference between triple-drug therapy (cyclosporine A, prednisolone, and azathioprine) and double-drug therapy (cyclosporine A and prednisolone) in any of the reported outcome measures. There was a non-significant trend for better graft survival under the triple therapy (OR 0.82, 95% CI 0.61 to 1.16). Adverse reactions reported were hypertension (more frequent in the triple therapy group), increased rates of and carcinomas.

Comment: The quality of evidence is downgraded by imprecise results (few outcome events) and study quality.

    References

    • Kunz R, Neumayer HH. Maintenance therapy with triple versus double immunosuppressive regimen in renal transplantation: a meta-analysis. Transplantation 1997 Feb 15;63(3):386-92. [PubMed][DARE]

Primary/Secondary Keywords