A Cochrane review [Abstract] 1 included 5 studies with a total of 292 subjects. Comparisons made within the RCTs were squeezable versus rigid feeding bottles (2 studies), breastfeeding versus spoon-feeding (1 study) and maxillary plate versus no plate (2 studies). No statistically significant differences were shown for any of the primary outcomes when comparing bottle types, although squeezable bottles were less likely to require modification. No statistically significant difference was shown for infants fitted with a maxillary plate compared to no plate. A statistically significant difference in weight (kg) at 6 weeks post-surgery was shown in favour of breastfeeding when compared to spoon-feeding (MD 0.47, 95% CI 0.20 to 0.74).
Comment: The quality of evidence is downgraded by imprecise results (limited study size for each comparison) and by limitations in study quality.
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