Levonorgestrel Combined with Ethinyloestradiol for Postcoital Contraception

A Cochrane review [Abstract] 1 included 9 trials with a total of 6894 women. Mifepristone (all doses) (RR 0.14, 95% CI 0.05 to 0.41; 3 trials, n=2144) and levonorgestrel 1.5mg (RR 0.57, 95% CI 0.39 to 0.84; 6 RCTs, n=4 750) were more effective than the Yuzpe regimen (levonorgestrel 0.5 mg + ethinyloestradiol 100 µg twice at 12 h intervals) in preventing pregnancy.

The following decision support rules contain links to this evidence summary:

• Levonorgestrel alone for postcoital contraception http://www.ebmeds.org/ebmeds/ebmeds_home.asp?mode=scripts&submode=view&id=scr00497&country=UK

References

• Shen J, Che Y, Showell E et al. Interventions for emergency contraception. Cochrane Database Syst Rev 2017;(8):CD001324. [PubMed]