Rarely a tumour in the prostate Prostate Cancer or elsewhere along the urinary tract (virtually almost never in men less than 50 years of age), benign urethral haemangiomas (also rare)
Investigations
For investigations into possible haematuria, see Haematuria.
Palpation of the prostate (touch per rectum) to detect a tumour
Samples to detect STDs are taken according to patient history or if there are signs of urethritis
Travel history: long-term haematospermia may be a symptom of schistosomiasis.
Semen analysis can be performed if there is uncertainty whether the patient really has haematospermia or if schistosomiasis is suspected.
Repeated haematospermia is an indication for further investigations (plasma prostate-specific antigen, ultrasonography of the prostate, cystoscopy), particularly in men above 50 years of age.
Treatment
Non-specific haematospermia does not need treatment.
Treatment of an underlying cause, e.g. infection
References
Ahmad I, Krishna NS. Hemospermia. J Urol 2007 May;177(5):1613-8. [PubMed]
Manoharan M, Ayyathurai R, Nieder AM, Soloway MS. Hemospermia following transrectal ultrasound-guided prostate biopsy: a prospective study. Prostate Cancer Prostatic Dis 2007;10(3):283-7. [PubMed]
Schwartz E, Pick N, Shazberg G, Potasman I. Hematospermia due to schistosome infection in travelers: diagnostic and treatment challenges. Clin Infect Dis 2002 Dec 1;35(11):1420-4. [PubMed]