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Evidence summaries

Duration of Adjuvant Chemotherapy for Patients with Non-Metastatic Colorectal Cancer

Shorter duration (3-6 months) of adjuvant chemotherapy for non-metastatic colorectal cancer is not associated with poorer relapse free survival or overall survival than longer duration (9-12 months) chemotherapy. Level of evidence: "A"

A Cochrane review [Abstract] 1 included 5 studies with a total of 5 794 subjects. Treatments were always based on 5-FU. Shorter duration of chemotherapy (3-6 months) compared with longer duration (9-12 months) was not associated to poorer relapse free survival (RR 0.96, 95% CI 0.90 to 1.02) and overall survival (RR 0.96, 95% CI 0.91 to 1.02).

    References

    • Des Guetz G, Uzzan B, Morere JF, Perret G, Nicolas P. Duration of adjuvant chemotherapy for patients with non-metastatic colorectal cancer. Cochrane Database Syst Rev 2010;(1):CD007046. [PubMed]

Primary/Secondary Keywords