Nodular or Enlarged Thyroid Gland - Related Resources

Cochrane reviews

Iodised salt appears to be an effective means of improving iodine status, but no conclusions can be made about improvements in patient-oriented outcomes, such as physical and mental development in children and mortality Iodised Salt for Preventing Iodine Deficiency Disorders.
Levothyroxine therapy with non-suppressive doses appears to reduce the growth and volume of benign thyroid nodules in euthyroid subjects compared to placebo or no treatment. Levothyroxine Therapy for Benign Thyroid Nodules

Thyroxine treatment appears to be associated with decreased nodule volume in 17% of patients Suppressive Thyroxine Therapy for Solitary Thyroid Nodules.
Subtotal thyroidectomy appears to be the best choice of operation in patients with mild forms of Graves' disease in order to try to achieve a euthyroid state. Total thyroidectomy is probably the best operation for severe disease and large goiter in order to ensure that hyperthyroidism does not recur Thyroidectomy for Graves' Disease.

Jones MK. Management of nodular thyroid disease. The challenge remains identifying which palpable nodules are malignant. BMJ 2001 Aug 11;323(7308):293-4. [PubMed]

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