Childhood Depression - Related Resources

Cochrane reviews

Antidepressant medication appears to reduce the rate of depression recurrence in children and adolescents Prevention of Relapse and Recurrence of a Depressive Disorder in Children and Adolescents.
There is insufficient evidence to assess the comparative effectiveness of antidepressive medication, psychological therapies, or a combination of these interventions in the treatment of major depressive disorder in children and adolescents. Antidepressive medication alone may be associated with more suicidal ideations than psychological treatments alone Psychological Therapies Versus Antidepressant Medication for Depression in Children and Adolescents.
Targeted and universal depression prevention programmes compared with no intervention may reduce clinically significant depressive episodes in children and adolescentsPsychological Interventions for the Prevention of Depression in Children and Adolescents.
Antidepressants appear to be more effective than placebo for children and adolescents with best benefits for non-OCD anxiety disorders, intermediate for obsessive-compulsive disorder (OCD) and modest for major depressive disorder (MDD). The benefits appear to be greater than the risk of suicidal ideation/suicide attempt, but the benefit-to-risk ratios vary Clinical Response and Risk for Reported Suicidal Ideation and Suicide Attempts in Pediatric Antidepressant Treatment with Second-Generation Antidepressive Agents.

Suicide prevention programs seem to be effective in youth at high risk but there is insufficient evidence to either support or not to support curriculum-based suicide prevention programs in schools Suicide Prevention Programs for Children and Youth.

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