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Evidence summaries

Risk for Hypertension in Living Kidney Donors

Kidney donors may have a 5-mmHg increase in BP over that expected with normal ageing 5 to 10 years after donation. Level of evidence: "C"

A systematic review 1 including 48 studies with a total of 5145 subjects was abstracted in DARE. 11 were prospective and the remaining were retrospective. Twelve studies had a control group. BP was higher in donors than controls at least 5 years after donation: the WMD was 6 mmHg (95% CI: 2, 11) for systolic BP (4 studies) and 4 mmHg (95% CI: 1, 7) for diastolic BP (5 studies). There was no evidence of statistical heterogeneity. The data on hypertension (6 studies) were not pooled because of evidence of statistical heterogeneity; an increased risk of hypertension in donors was noted in one study.

    References

    • Boudville N et al. Meta-analysis: risk for hypertension in living kidney donors. Ann Intern Med 2006;145:185-196. [DARE]

Primary/Secondary Keywords