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Evidence summaries

Tazaroten in the Treatment of Psoriasis

Tazarotene appears to be effective in the treatment of psoriasis. Level of evidence: "B"

In a randomized controlled double-blind study 324 patients with plaque psoriasis were allocated into three groups: tazarotene gel 0.1%, tazarotene gel 0.05%, and vehicle 1. The duration of the study was 12 weeks. Both groups on active treatment did better than the vehicle group (p<0.001 with 0.1% gel, and p<0.05 with 0.05% gel).

Comment: The quality of evidence is downgraded by sparse data.

    References

    • Weinstein GD, Krueger GG, Lowe NJ, Duvic M, Friedman DJ, Jegasothy BV, Jorizzo JL, Shmunes E, Tschen EH, Lew-Kaya DA, Lue JC, Sefton J, Gibson JR, Chandraratna RA. Tazarotene gel, a new retinoid, for topical therapy of psoriasis: vehicle-controlled study of safety, efficacy, and duration of therapeutic effect. J Am Acad Dermatol 1997 Jul;37(1):85-92. [PubMed]

Primary/Secondary Keywords