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Evidence summaries

Maintenance Therapy with Atosiban for Inhibiting Preterm Birth after Threatened Preterm Labour

There is insufficient evidence of the effectiveness of maintenance therapy with atosiban to inhibit preterm birth after a period of threatened preterm labour. Level of evidence: "D"

The quality of evidence is downgraded by imprecise results (few patients and outcome events).

Summary

A Cochrane review [Abstract] 1 included 1 study with a total of 513 subjects. When compared with placebo, atosiban did not reduce preterm birth before 37 weeks (RR 0.89; 95% CI 0.71 to 1.12), 32 weeks (RR 0.85; 95% CI 0.47 to 1.55), or 28 weeks (RR 0.75; 95% CI 0.28 to 2.01). No difference was shown in neonatal morbidity, or perinatal mortality.

Clinical comments

Note

Date of latest search: 28 August 2013

References

  • Papatsonis DN, Flenady V, Liley HG. Maintenance therapy with oxytocin antagonists for inhibiting preterm birth after threatened preterm labour. Cochrane Database Syst Rev 2013;(10):CD005938. [PubMed]

Primary/Secondary Keywords