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Evidence summaries

Terlipressin for Acute Esophageal Variceal Hemorrhage

Terlipressin is more effective than placebo in reducing mortality in esophageal variceal bleeding. Level of evidence: "A"

A Cochrane review [Abstract] 1 included 7 studies with a total of 443 subjects. Terlipressin was associated with a statistically significant reduction in all cause mortality compared to placebo (RR 0.66, 95% CI 0.49 to 0.88). According to studies with limited power, there was no significant difference between terlipressin and somatostatin or terlipressin and endoscopic treatment.

References

  • Ioannou G, Doust J, Rockey DC. Terlipressin for acute esophageal variceal hemorrhage. Cochrane Database Syst Rev 2003;(1):CD002147. [PubMed]

Primary/Secondary Keywords