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Evidence summaries

Changes of Bone Density after Exposure to Oral Anticoagulants

Oral anticoagulant treatment may be associated with slight decrease in bone density in ultra distal radius, but there is no evidence of significant decrease at other sites. Level of evidence: "C"

A systematic review 1 including 9 cross-sectional studies was abstracted in DARE. There was some evidence of decreased bone density in ultra distal radius (SMD = -0.39, 95% CI -0.67 to -0.10) but not in distal radius, lumbar spine, femoral neck or femoral trochanter.

    References

    • Caraballo PJ, Gabriel SE, Castro MR, Atkinson EJ, Melton LJ 3rd. Changes in bone density after exposure to oral anticoagulants: a meta-analysis. Osteoporos Int 1999;9(5):441-8. [PubMed][DARE]

Primary/Secondary Keywords