Gestational Trophoblastic Disease - Related Resources

Cochrane reviews

Dactinomycin is superior to methotrexate in achieving primary cure without significantly increasing toxicity in low risk gestational trophoplastic neoplasia First Line Chemotherapy in Low Risk Gestational Trophoblastic Neoplasia.
Prophylactic chemotherapy may reduce the risk of progression to gestational trophoblastic disease in women with complete hydatidiform mole compared with no treatment Prophylactic Chemotherapy for Hydatidiform Mole to Prevent Gestational Trophoblastic Neoplasia.
The combination of methotrexate, actinomycin D and chlorambucil (MAC)might possibly be as effective with less toxicity as the combination of cyclophosphamide, hydroxyurea, actinomycin D, methotrexate, doxorubicin, melphalan and vincristine (CHAMOCA) for high-risk gestational trophoblastic disease, although the data are insufficient.

Seckl MJ, Sebire NJ, Berkowitz RS. Gestational trophoblastic disease. Lancet 2010 Aug 28;376(9742):717-29. [PubMed]

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