A systematic review 1 including 90 studies with a total of 656 subjects was abstracted in DARE. Eighty-nine of these studies were cohort studies or uncontrolled case series. One study was an RCT but the randomisation was not relevant to the review question. Across all treatments, 14% of patients achieved a complete response, 40% a partial response and 46% no response. The largest numbers of complete responses were reported with azathioprine (18 out of 109; 17%), cyclophosphamide (22 out of 83; 27%) and rituximab (10 out of 41; 24%). However, 36 to 42% of the patients had no response to these three treatments.
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