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Evidence summaries

Tricyclic Antidepressant for Depression in Children and Adolescents

Tricyclic antidepressants appear not to be more efficient than placebo in the treatment of depression in children and adolescents. Level of evidence: "B"

A Cochrane review [Abstract] 1 included 14 studies with a total of 590 participants. No overall difference was found for the primary outcome of response to treatment compared with placebo RR 1.07, 95% CI 0.91 to 1.26; 9 trials, N = 454). Treatment with a tricyclic antidepressant caused more vertigo (RR 2.76, 95% CI 1.73 to 4.43; 5 trials, N = 324), orthostatic hypotension (RR 4.86, 95% CI 1.69 to 13.97; 5 trials, N = 324), tremor (RR 5.43, 95% CI 1.64 to 17.98; 4 trials, N = 308) and dry mouth (RR 3.35, 95% CI 1.98 to 5.64; 5 trials, N = 324) than did placebo,

References

Primary/Secondary Keywords