A systematic review 1 including 65 prospective controlled trials with 42 different medications was abstracted in DARE. The results were as follows:
Risk difference with benzodiazepine vs placebo for delirium: -4.9 cases of delirium/100 patients (95% CI -9.0 to -0.7).
Risk difference with benzodiazepines vs placebo for seizure: -7.7 cases of seizures/100 patients (95% CI -12.0 to -3.5).
Risk difference with long acting as opposed to short acting benzodiazepine for seizure: -6.7 cases of seizure/100 patients (95% CI -13.0 to 0.0).
Risk difference with phenothiazine vs placebo for delirium: 0.0
Risk difference with phenothiazine vs placebo for seizure: +4.6 cases of seizure/100 patients (95% CI -2.6 to 11.9).
Risk difference with phenothiazine vs cross-tolerant medication (benzodiazepine or paraldehyde) for seizure: +11.4 (95% CI +6.2 to +16.6).
The following decision support rules contain links to this evidence summary:
Primary/Secondary Keywords