The certainty of the evidence is downgraded by imprecion (few events).
A Cochrane review [Abstract] 1 included 47 studies assessing gonadotropins for intrauterine insemination. Gonadotropins versus anti-oestrogens: Gonadotropins improved live birth rate (OR 1.37, 95% CI 1.05 to 1.79; I² = 30%; 5 studies, n=1924). Gonadotropins with GnRH antagonist versus gonadotropins alone: There was no significant difference in live birth rate (OR 1.5, 95% CI 0.52 to 4.39; I² = 81%; 3 studies, n=419). Aromatase inhibitors versus gonadotropins: Aromatase inhibitors had lower live birth rate (OR 0.49, 95% CI 0.34 to 0.71; I²=0%; 2 studies, n=651). None of the agents compared lead to significantly higher multiple pregnancy rates.
Date of latest search: 2021-12-15
Primary/Secondary Keywords