The certainty of evidence is downgraded by study limitations.
A Cochrane review [Abstract] 1 included 15 studies with a total of 768 subjects. Comparison with prednisolone alone, calcineurin inhibitors (CNIs, like cyclosporine and tacrolimus) with reduced-dose prednisolone or without prednisolone showed little or no difference to the number achieving complete remission (RR 0.99, 95% CI 0.93 to 1.05; 8 trials, n=492), complete or partial remission (RR 1.01, 95% CI 0.96 to 1.05; 4 trials, n=269), or relapse (RR 0.73, 95% CI 0.51 to 1.03; 7 trials, n=422).The comparison of different prednisolone regimens and doses with no specific treatment (4 trials) yielded very low evidence because of very few participants. However, there was a clear and strong trend towards positive effect for complete or partial remission and less relapses with prednisolone.
Date of latest search: 2022-11-07
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