A Cochrane review [Abstract] 1 included 23 studies with a total of 1 459 subjects. NSAIDs reduced creatinine clearance by 16 ml/min (95% CI 5 to 28) and potassium output by 38 mmol/day (95% CI 19 to 56) on the first day of surgery compared to placebo. There was no significant difference in serum creatinine on the first day (0 umol/l, 95%CI -5 to 4) compared to placebo. No significant reduction in urine volume during the early postoperative period was found. There was no significant difference in serum creatinine in the early postoperative period between patients receiving diclofenace, ketorolac, indomethacin, ketoprofen or etodolac. No cases of postoperative renal failure requiring dialysis were described. The trials were homogenous for the primary outcome.
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