A Cochrane review [Abstract] 1 included 3 studies with a total of 335 subjects. Two trials compared pyrimethamine plus sulfadiazine (P+S) with pyrimethamine plus clindamycin (P+C). One trial compared P+S with trimethoprim-sulfamethoxazole (TMP-SMX). All three studies were relatively small and did not show significant differences in the treatment effects between the different drug regimens.
Comment: The quality of evidence is downgraded by imprecise results (limited study size for each comparison).
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