A Cochrane review [Abstract] 1 included 21 trials in low or middle-income countries (n=142 496). When compared with iron and folate supplementation, MMS decreased the number of low birthweight babies (RR 0.88, 95% CI 0.85 to 0.91; 18 trials, n=6 8 801), small-for-gestational-age babies (RR 0.92, 95% CI 0.88 to 0.97; 17 trials, n=57 348). No statistically significant differences were shown for the outcomes of preterm births and perinatal mortality, or maternal mortality in any of the comparisons.
Comment: The quality of evidence is downgraded by study quality (unclear allocation concealment in half of the studies).
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