A Cochrane review [Abstract] 1 included one study with a total of 481 subjects. The odds ratio for losing three or more lines of vision at 52 weeks with interferon alfa-2a versus placebo was 1.60 (95% CI 1.01 to 2.53), i.e., interferon was associated with a 60% increased odds of decreased visual acuity (p=0.04).
Comment: The quality of evidence is downgraded by imprecise results (one single study).
Primary/Secondary Keywords