A Cochrane review 2 (abstract , review [Abstract]) included 19 studies on the effectiveness of newer generation antidepressants for depressive disorders in children and adolescents, with a total of 3335 subjects.There was evidence that those treated with an antidepressant had lower depression severity scores and higher rates of response/remission than those on placebo. However, the size of these effects was small with a reduction in depression symptoms of 3.51 on a scale from 17 to 113 (14 trials; N = 2490; MD -3.51; 95% CI -4.55 to -2.47). Remission rates increased from 380 per 1000 to 448 per 1000 for those treated with an antidepressant. There was evidence of an increased risk (58%) of suicide-related outcome for those on antidepressants compared with a placebo (17 trials; N = 3229; RR 1.58; 95% CI 1.02 to 2.45). This equates to an increased risk in a group with a median baseline risk from 25 in 1000 to 40 in 1000.
Comment: The quality of evidence is downgraded by indirectness (differences between trials in the definition of response, clinical significance of the effect size unclear).
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