A Cochrane review [Abstract] 1 included 10 studies with a total of 143 participants (113 with myotonic dystrophy type 1 and 30 with myotonia congenita). Twelve different drugs were used in the studies which were of poor quality. Two small crossover studies without a washout period demonstrated a significant effect of imipramine and taurine in myotonic dystrophy. One small crossover study with a washout period demonstrated a significant effect of clomipramine in myotonic dystrophy. Meta-analysis was not possible.
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