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KaarloSimojoki

Recognition of Alcohol and Drug Abuse

Essentials

  • Abuse of alcohol or drugs often causes health problems that make the user seek medical care, but the patients are nevertheless not able or willing to tell about the abuse. Every patient contact makes it possible to recognize the abuse and, in the best case, start treatment even at an early stage before severe harm occurs Brief Interventions for Risky Use of Alcohol.
  • The best way to address the problem is to ask the patient directly, clearly and without judgement about the use. Observing clinical signs and discussing the findings with the patient helps in the assessment of the situation.
  • Questionnaires, e.g. AUDIT Opportunistic Screening for Alcohol Use Disorders in Primary Care, can be used as assistive tools.
  • If necessary, laboratory tests may be utilized.

Direct detection of alcohol or drug use

  • Use of alcohol can be detected from the typical odour of the breath, by using a breath analyzer, or by assessing blood alcohol concentration.
  • Use of drugs is detected from a urine sample with a qualitative screening panel. Depending on local legislation and other regulations, such drug testing may require the patient's permission (informed consent). When drug intoxication or abuse is suspected, more extensive investigations are required and the urine sample is sent to a specialized laboratory.
  • There may be country-specific regulations concerning drug testing at the work place and the clinical use of drug tests.
  • See also Brief interventions for risky use of alcohol Brief Interventions for Risky Use of Alcohol.

Symptoms induced by alcohol and drug abuse

  • Various unspecific signs may suggest alcohol or drug abuse.
    • Absenteeism from work or school or decline in performance
    • Decline in general functioning, inability to concentrate
    • Behavioural disturbances in children and adolescents
    • Injection marks and infections at the injection sites
    • Intoxications, increased proneness to accidents
    • Sleeplessness and depression
    • Vague abdominal complaints and unexplainable pain
    • Problems with human relations in the private life or at work
    • Financial or housing problems
    • Demanding and manipulative conduct of the patient at the surgery
    • Elevated blood pressure, cardiac arrhythmias
  • Acute symptoms include fluctuation in the level of consciousness and mood, hallucinations
    • Consider neurological and psychiatric disorders in the differential diagnostics.
  • Note possible concurrent medical disorders such as a head injury, diabetes or an infection.

Structured interview concerning alcohol use

  • AUDIT (Alcohol Use Disorders Identification Test) is the most recommended measure to assess excessive alcohol use Opportunistic Screening for Alcohol Use Disorders in Primary Care (see program Audit). It has a sensitivity of approximately 90%. The limit of risk use is 8 points for men and 6 points for women.
  • In hectic out-of-hours settings, the third question of AUDIT (risk limit 2 points) or the AUDIT-C-version including only the first three questions (risk limit 6 points for men and 5 points for women) may be used.
  • The alcohol tolerance of the body decreases by age. According to Finnish guidance, the average risk threshold doses for the elderly are at maximum 8 standard doses of alcohol in a week and 3 doses at any one time. One standard unit contains 12 g of absolute alcohol. Note that the point limits used in AUDIT are designed for working age persons.
  • The patient can be encouraged to use internet-based self-assessment tests of alcohol problems: these may make it easier to take the problems up in a discussion. Relevant material may also be found within psychiatric evaluation forms.
  • Several other tests are available, the majority of which are based on the Michigan Alcoholism Screening Test (MAST) The Validity of the Michigan Alcoholism Screening Test (Mast). An abridged version of this is called Veterans Administration Screening Test (VAST).
  • When estimating the total amount consumed, it is advisable to ask about the different types of alcoholic drinks one by one (beer, cider, wine, spirits). It is often easier for a patient to describe questions that include words such as “can”, “bottle” or “pint”, instead of “dose”.

Laboratory tests and other measurements for detecting risky or excessive alcohol use

Breathalyser

  • Measurement of alcohol concentration in the exhaled air using a breathalyser, performed in cooperation with the patient, is an effective way to assess both risky and excessive alcohol use and the possibility of alcohol dependence. Individual situation should be taken into account (e.g. acute life crisis)
    • A result indicating a concentration of less than 0.1 percent alcohol in the blood when measured during an appointed visit already suggests risky use.
    • Alcohol dependence is likely if the result exceeds 0.1 percent.
    • If the result is over 0.15 percent without any signs of intoxication, or if it exceeds 0.3 percent, alcohol dependence can be considered as confirmed.

Laboratory tests

  • Laboratory tests that indirectly indicate risky or excessive alcohol intake may be used in addition to interviewing and direct measurement of alcohol concentration. Phosphatidylethanol (PEth) concentration is a specific indicator of alcohol consumption. The sensitivity of other laboratory tests is low (30-40%) especially in the early phase of excessive use.

Phosphatidylethanol (PEth)

  • PEth is an atypical phospholipid that is formed in the body only in association with alcohol use and through the activity of phospholipase D. Following ample and regular use of alcohol, the blood cells become enriched with PEth (alcohol use over 60 g/day for a period of more than one week).
  • A single occasion of using alcohol or getting drunk will not increase PEth concentration.
  • The concentration correlates positively with the amount of alcohol consumed within the last 2 weeks.
  • Half-life is about 4 days. Depending on the amount of alcohol used, PEth can be detected 2-4 weeks after stopping the use of alcohol.
  • Reference value is below 0.30 µmol/l.
    • If alcohol use exceeds the risk limit (50 g/day) and continues for more than 2-3 weeks, PEth concentration increases over the reference value. In persons who regularly use alcohol daily in large quantities and for long periods, even months, the concentration is clearly elevated and may exceed the reference limit of 0.30 µmol/l even manyfold.
  • Concentration below 0.05 µmol/l indicates that alcohol has not been used, or it has been used only occasionally.
  • Low-risk drinking usually increases PEth level only slightly and it remains below 0.30 µmol/l.

Carbohydrate deficient transferrin (CDT, serum desialotransferrin)

  • Serum concentration increases when daily alcohol consumption exceeds 5 doses per day (50-80 g) for a period of a few weeks.
  • Half-life is 15 days. Consequently, it is well-suited for monitoring reduction in alcohol use or abstinence, particularly in men.
  • The test is sensitive in the recognition of alcohol dependence (sensitivity over 90%) but in the early recognition of heavy alcohol intake the sensitivity is as low as with glutamyltransferase (GGT) (about 30%).
  • CDT may be of help in detecting heavy alcohol use in cases where clinical history, MCV and GGT have not given clarity.
  • The upper reference limit is 20 U/l in men and 26 U/l in women (< 2.5% in all). Even a small deviation from the reference range is significant.
  • Disialotransferrin (serum DST) is a form of transferrin that constitutes a part of the carbohydrate-deficient transferrin (CDT). The result is reported as a percentage of the total transferrin.
    • Reference values: men < 1.8%, women < 1.6%
    • The determination method for DST is much more specific compared to CDT.
  • Increased concentrations can also be found in multiple sclerosis, primary biliary cirrhosis, chronic active hepatitis, and in the rare carbohydrate deficiency glycoprotein syndrome.

Serum glutamyltransferase (GGT)

  • Increased concentrations in 70-90% of people addicted to alcohol
  • The sensitivity in recognition of heavy alcohol use especially in young persons is only 10-30%.
  • The test is suitable to follow up decline of alcohol use. Value becomes normal during 2-3 weeks of abstinence. One-off drinking does not cause elevation.
  • Values normalize slowly (half-life about 26 days) after drinking is stopped.
  • Increased concentrations are also seen in association with the e.g. hepatobiliary diseases, diabetes and obesity.
  • Medicines, such as amitriptyline, barbiturates, phenazone, phenytoine and warfarin, may increase GGT concentrations.

MCV

  • Increased values in 48-90% of alcoholics
  • MCV value 100 fl or more without anaemia is, particularly in men, usually caused by alcohol abuse.
  • MCV is normalized slowly over several months of alcohol abstinence (half-life 120 days).
  • Not a suitable indicator for monitoring abstinence
  • For sources of error, see Macrocytosis (Increased MCV) (increased MCV).

Applying a structured interview for assessing drug addiction

Severity of Dependence Scale - SDS

Modified from article Gossop M, Griffiths P, Powis B et al. Severity of dependence and route of administration of heroin, cocaine and amphetamines. Br J Addict 1992;87(11):1527-36. [PubMed]
Name:__________________________Date:_________________________
Instructions
  1. Consider which substance has caused you the most addiction problems during the past year.
  2. Write down in this form the name of the substance (e.g. Valium, heroin, Subutex, Temgesic, amphetamine). If you experience problems with two or more substances, fill out one form for each substance. If you are not able to reliably recognize your problems with regard to individual substances, use only one form, write down the substances you use and answer the questions according to the problems you have experienced with these substances during the past year.
  3. Read each question carefully and mark the option that best describes your situation.
  4. If any of the questions is difficult to answer, do not hesitate to ask the personnel for help.
Name of the substance:__________________________________________________________
Not at all
0 points
To some extent
1 point
Moderately
2 points
Strongly
3 points
1. Are you worried about your use of __________________________ ?
2. Does the possibility or thought of not being able to get the next dose of the substance make you anxious or worried?
3. Do you experience that your use of the substance has been out of control?
4. Have you thought of stopping the use of _______________________ ?
5. Do you find it difficult to stop the use or to be without _____________________________?
Total points