Comment: The quality of evidence is downgraded by imprecise results (one study, with few patients and wide confidence intervals).
A Cochrane review [Abstract] 1 included 4 studies with a total of 820 subjects. In one study of women with subclinical hypothyroidism (SCH) and positive or negative anti-TPO antibodies (autoimmune disease), thyroxine replacement improved live birth rate (RR 2.13, 95% CI 1.07 to 4.21; 1 RCT, n=64; low-quality evidence) compared with placebo or no treatment, and led to similar miscarriage rates. In women with normal thyroid function and thyroid autoimmunity (euthyroid autoimmune thyroid disease), treatment with thyroxine replacement compared with placebo or no treatment led to similar live birth rates (RR 1.04, 95% CI 0.83 to 1.29; 2 RCTs, n=686; I²=46%; low-quality evidence) and miscarriage rates (RR 0.83, 95% CI 0.47 to 1.46, 2 RCTs, n=686, I²=0%; low-quality evidence).
Date of latest search: 2019-12-30
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