Memory Complaints, Mild Cognitive Impairment and Dementia - Related Resources
Cochrane reviews
Statins appear not to be effective in preventing Alzheimer's disease or dementia given in late life to individuals at risk of vascular disease Prevention of Dementia by Statins.
Donepezil appears not to be effective in preventing the development of Alzheimer's disease during 3 years' treatment in patients with mild cognitive impairment (MCI, MMSE > 23) and its use is associated with a significant incidence of side effects. Donepezil appears to be associated with a modest and clinically questionable benefit on a 13-item the ADAS-Cog scale but not on other measures of cognitive function Donepezil for Mild Cognitive Impairment.
Cholinesterase inhibitors do probably not have an effect on progression to dementia or cognitive test scores in mild cognitive impairment but may increase the risk of particularly gastrointestinal adverse events Cholinesterase Inhibitors for Mild Cognitive Impairment.
Literature
Clinical practice reviews
Iliffe S, Pealing L. Subjective memory problems. BMJ 2010 Mar 19;340():c1425. [PubMed]