52 trials with 10,269 participants were included in a Cochrane review [Abstract] 1.
Praziquantel 40 mg/kg compared to placebo reduced parasitological treatment failure at one month post-treatment (RR 3.13, 95% CI 1.03 to 9.53, 2 trials, 414 participants). Oxamniquine 40 mg/kg compared to placebo reduced parasitological treatment failure at three months (RR 8.74, 95% CI 3.74 to 20.43, 2 trials, 82 participants). The optimal dosage of both drugs was 40 mg/kg, smaller doses being less effective and bigger doses offered no additional benefit.
Comment: The quality of evidence is downgraded by imprecise results (few patients).
Primary/Secondary Keywords