Brain and Spinal Cord Tumours - Related Resources

Cochrane reviews

Antiepileptic drugs phenytoin, phenobarbital or divalproex may not be effective in preventing postoperative seizures in patients with brain tumours Antiepileptic Drugs for Preventing Seizures in People with Brain Tumours.
Temozolomide, when given in primary glioblastoma multiforme (GBM) in both concomitant and adjuvant phases may prolong survival and delay progression compared to radiotherapy alone. In recurrent GBM, temozolomide may improve time to progression but does not improve overall survival, when compared with standard chemotherapy Temozolomide for High Grade Glioma.
Altered dose-fractionating schemes compared to conventional dose-fractionating appear to bring no benefit in terms of survival, tumour control or symptom control for patients with newly diagnosed multiple brain metastases Whole Brain Radiotherapy for the Treatment of Newly Diagnosed Multiple Brain Metastases.

Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med 2008 Jul 31;359(5):492-507 [PubMed]