A Cochrane review [Abstract] 1 included 5 studies with a total of 239 subjects comparing 1-stage implant placement with 2-stage placement. On a patient, rather than per implant basis, the meta-analyses showed no statistically significant differences for prosthesis (RR 1.87, 95% CI 0.33 to 10.40; 3 studies, n=153) and implant failures (RR 1.39, 95% CI 0.59 to 3.27; 4 studies, n=210) at 6 to 12 months. However, trends suggested less implant failures with the 2-stage (submerged) approach especially in fully edentulous patients.
Comment: The quality of evidence is downgraded by study quality (inadequate or unclear allocation concealment and lack of blinding) and by imprecise results (wide confidence intervals).
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