Gynaecological Tumours - Related Resources

Cochrane reviews

Addition of cisplatin-based chemotherapy to radiotherapy seems to increase survival and decrease disease progression in the adjuvant treatment of early stage cervical cancer with risk factors for recurrence, although the evidence is insufficient Adjuvant Platinum-Based Chemotherapy for Early Stage Cervical Cancer.
Adding neoadjuvant chemotherapy to surgery may not to improve overall survival in early or locally advanced cervical cancer Neoadjuvant Chemotherapy Plus Surgery Versus Surgery for Early or Locally Advanced Cervical Cancer.
Groin surgery may be more effective than groin irradiation in the prevention of groin recurrence in early vulvar cancer Primary Groin Irradiation Vs. Primary Groin Surgery for Early Vulvar Cancer.
Neoadjuvant chemoradiotherapy seems to be of some benefit for patients with irresectable vulvar tumour or groin nodes, when followed by excision of at least tumour bed and groin nodes Neoadjuvant Chemoradiation for Advanced Primary Vulvar Cancer.
Vaginal hysterectomy appears to have significant benefits over abdominal hysterectomy and should be preferred. Laparoscopic hysterectomy appears to have no benefits over vaginal approach and the operation time is longer. Compared to abdominal hysterectomy, laparoscopic approach has many advantages but again the operation time is longer and there is a greater risk of urinary tract injuries Route of Hysterectomy for Benign Gynaecological Disease.
Lymphadenectomy appears not to decrease the risk of death or disease recurrence compared with no lymphadenectomy in women with presumed stage I endometrial cancer Lymphadenectomy for the Management of Endometrial Cancer.
More intense regimens of cytotoxic drugs, preferably containing paclitaxel or platinum, give longer progression-free survival than less intensive ones for advanced endometrial adenocarcinoma but at the expense of increased toxicity. For benefits on overall survival or quality of life the evidence is insufficient Chemotherapy for Advanced Endometrial Carcinoma.
Interval debulking surgery for advanced epithelial ovarian cancer seem to be effective in cases wherein the primary surgery was not performed by the gynecologic oncologists, but the evidence is insufficient Interval Debulking Surgery for Advanced Epithelial Ovarian Cancer.
Intraperitoneal chemotherapy in the primary treatment of advanced ovarian cancer improves both overall and disease free survival Intraperitoneal Chemotherapy for Ovarian Cancer.
Uterine artery embolization (UAE) for symptomatic uterine fibroids offers a shorter hospital stay and a quicker return to routine activities as compared to hysterectomy or myomectomy but is associated with more minor complications Uterine Artery Embolization Versus Myomectomy for Symptomatic Uterine Fibroids.
Total vs. subtotal hysterectomy for benign gynaecological conditions has probably no difference in the rates of incontinence, constipation or measures of sexual function Total Versus Subtotal Hysterectomy for Benign Gynaecological Conditions.

Other evidence summaries

Nafarelin appears to decrease uterine bleeding, improve haematologic parameters and symptoms in patients with leiomyomas Nafarelin in the Treatment of Leiomyomas.

Literature

Hennessy BT, Coleman RL, Markman M. Ovarian cancer. Lancet 2009 Oct 17;374(9698):1371-82. [PubMed]
Stewart EA. Uterine fibroids. Lancet 2001 Jan 27;357(9252):293-8. [PubMed]
Levy BS. Modern management of uterine fibroids. Acta Obstet Gynecol Scand 2008;87(8):812-23. [PubMed]
Blair AR, Casas CM. Gynecologic cancers. Prim Care 2009 Mar;36(1):115-30, ix. [PubMed]

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References

Gynaecological Tumours - Related Resources

Cochrane reviews

Other evidence summaries

Literature